|
Drug or Class
|
Black Box Warnings
|
|
Amiodarone
|
Pulmonary toxicity, avoid with pacemakers
|
|
ACEi, ARB
|
Fetal toxicity
|
|
Abacavir/Lamuvidine
|
Lactic acidosis, hepatomegaly, hepatitis
|
|
Acetaminophen
|
Liver failure
|
|
Aminoglycosides
|
Ototoxicity, nephrotoxicity
|
|
Anabolic steroids
|
Hepatitis, liver tumors, blood lipid changes
|
|
Aspirin
|
Reyes syndrome in children
|
|
Atomoxetine
|
Suicide
|
|
Beta blocker
|
MI with abrupt stopping
|
|
Calcineurin inhibitors (tacrolimus)
|
Cancer
|
|
Diuretics
|
Volume, electrolyte depletion
|
|
Enoxaparin (LMWH)
|
Spinal/epidural hematoma
|
|
Estrogen
|
Heart attack, stroke, breast cancer, pulmonary embolism
in post-menopausal
|
|
Infliximab
|
Infection, malignancy
|
|
Iron
|
Fetal toxicity
|
|
Isotretinoin
|
Birth defects
|
|
Ketoconazole
|
Hepatotoxicity
|
|
LABA
|
Sudden death
|
|
Lamotrigine
|
Rash
|
|
Metformin
|
Lactic acidosis
|
|
Methadone (opiod)
|
Respiratory depression, QT prolongation
|
|
Metoclopramide
|
Tardive dyskinesia
|
|
NSAID
|
GI bleeding, ulcers
|
|
Olanzapine
|
Delirium, sedation, avoid in dementia related psychosis
|
|
Paroxetine (SSRI)
|
Suicide
|
|
Pioglitazone
|
Worsen heart failure, avoid with NYHA class 3, 4
|
|
SGLT2 inhibitors
|
Ketoacidosis
|
|
Stavudine
|
Lactic acidosis
|
|
Telithromycin
|
Respiratory failure with myasthenia gravis
|
|
Warfarin
|
Bleeding
|
Source: Pharmacist Letter. List of Products with
"Black Box" Warnings.
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