Dosing
Weight management: 0.6 mg injected once daily for one week, then increase at weekly intervals to a target dose of 3 mg daily. Patients may delay the increase in dose by a week if the higher dose is not tolerated. Patients who cannot tolerate the 3mg daily dose, or those who have not lost 4%of their body weight within 16 weeks should discontinue this medication.
Diabetes, Type 2: 0.6 mg injected once daily for one week, then increase to 1.2 mg daily. If glycemic control is not achieved, you can increase to 1.8 mg once daily.
**According to Facts & Comparisons, no maximum dose has been established**
Black Box Warning
Liraglutide was found to cause dose and duration-dependent thyroid C-cell tumors in rats; it has not yet been established whether or not it causes these tumors in humans. However, liraglutide is contraindicated in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
Common Side Effects
Headache, negative GI effects (constipation or diarrhea, nausea, decreased appetite, dyspepsia), weakness/lack of energy, irritation at injection site.
Administration Pearls
- Victoza is only to be injected subcutaneously in the following sites: upper arm, thigh, abdomen
- May be administered without regard to meals or time of day
- Do not use if cloudy or containing particulate matter
- Change needle prior to each administration
- If also using insulin, do not inject Victoza directly adjacent to the site of insulin injection
Instructional Video
References
1. Lexicomp. Victoza. Accessed 7/30/2015.<http://online.lexi.com.proxy.lib.uiowa.edu/lco/action/doc/retrieve/docid/patch_f/2144379#thclist>
2. Facts & Comparisons. Victoza. Accessed 7/30/2015.
<http://online.factsandcomparisons.com.proxy.lib.uiowa.edu/MonoDisp.aspx?monoID=fandc-hcp15525&quick=880418%7c5&search=880418%7c5&isstemmed=True&NDCmapping=-1&fromTop=true#firstMatch>
3. Youtube. Victoza Pen Quick Guide. Accessed 7/30/2015. <https://youtu.be/BS39qXij-Jg>
No comments:
Post a Comment