Drug Information Question 2 - Lotemax Drug Supply

Drug Information Question

How long does Lotemax (loteprednol etabonate ophthalmic gel) 0.5% bottle containing 5 grams of gel last when taking four times a day for 1 week?

Answer

1 drop of water is 0.05ml which is 0.05g. 

0.05g per drop X 4 times daily X 2 eyes = 0.4g

5g per bottle / 0.4 g used per day = 12.5 days

The gel is likely more viscous than water so I estimate that at twice the viscosity a drop of gel would be 0.1g per drop

0.1g per drop X 4 times daily X 2 eyes = 0.8g

5g per bottle / 0.8 g used per day = 6.25 days

The bottle should last the patient approximately a week.  Since use of steroid eye drops long term is not recommended, this is appropriate for the patient. 

According to the package insert the directions for Lotemax use are follows: “Apply one to two drops of LOTEMAX into the conjunctival sac of the affected eye four times daily beginning the day after surgery and continuing throughout the first 2 weeks of the postoperative period.”

Other information    

Lotemax [package insert]. Tampa, FL: Bausch & Lomb Incorporated; 2015.

http://www.bausch.com/Portals/107/-/m/BL/United%20States/USFiles/Package%20Inserts/Pharma/lotemaxgel-package-insert.pdf